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Posted on JUNE, 27 2015

For the first time, a new research has demonstrated that the activity of intestinal bacteria, it is possible to quantify and classify the effects of different diseases. Microbiota, the human intestinal flora that consists of millions of bacteria, can now indicate the functioning and health of the human body. In this sense, Microbiota can be considered as an additional organ in the body, which interacts with each other and also with the human boy.

The excepts of the research done jointly by the University of Valencia and the Foundation for the Promotion of Health and Biomedical Research of the Valencian Community (FISABIO) are published in the journals Scientific Reports and ISME Journal, of Nature Publishing Group. Based on the composition of different chemical species found in the gastrointestinal tract oh human beings, different pathophysiologies, such as infectious diarrhea, and obesity, can be segregated.

However, the changes in the Microbiota were also observed in some healthy individuals, when examined across different demography, geography, diet pattern, and or effect of antibiotic treatments. In addition, it is yet to be confirmed whether multiple diseases or pathophysiologies can induce similar gastrointestinal changes. The researchers studied the composition and diversity of Metabolome, which are chemical species produced by intestinal bacteria in different groups of patients

The study also reveals that patients with similar infectious diarrhea show a specific (common) gastrointestinal metabolic profile, regardless of their Body Mass Index (BMI) and medical history. The researchers have demonstrated that the changes induced a certain pathogen, for say 'C. Difficile', are different from those caused by 'Escherichia coli'. They have concluded that, “Different intestinal pathogens produce various alterations.” Putting light on the study, Andrés Moya, Professor of Genetics at the University of Valencia said, “Defining such changes is important because these may have an effect not only on the progression of the disease but also on our health.”

The research will find a new way of studying the effect of diseases and finding the most appropriate treatment procedure for the same. Usually, the top of the functional hierarchy is affected by the changes imposed by this pathophysiology. Hence, this provides al altogether new opportunity to the studying the way heterogeneities, which are at the lower levels of the functional hierarchy, end up in the same chemical pattern, specific to different diseases. Now it will be possible to segregate pathophysiologies, such as immune response or obesity and pathogenic bacteria infections based on metabolic patterns found in the gastrointestinal tract.

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